Tesamorelin — a detailed review of the peptide
Tesamorelin is a synthetic ghrelin-releasing hormone (GHRH) analogapproved by the FDA for the treatment of lipodystrophy in HIV-infected patients. , but it is also being investigated in the context of anti-aging therapy, fat burning and recovery.
1. Mechanism of action
Tesamorelin acts through the hypothalamic-pituitary axis:
- Binds to GHRH receptors in the pituitary gland.
- Stimulates the release of growth hormone (GH).
- GH enhances the synthesis of IGF-1 in the liver, which leads to:
- — Acceleration of lipolysis (breakdown of fat, especially visceral).
- ️ Improve muscle tone.
- Нейро Neuroprotection and cognitive support.
Difference from other GHRPs (for example, GHRP-2/6):
- Thesamorelin does not directly affect ghrelin receptors, so it does not cause severe hunger.
- It gives a more physiological release of GH (closer to the natural pulsation).
2. Main effects
① Visceral fat reduction (main application)
- Reduces the volume of abdominal fat by 15-20% in 3-6 months (studies in HIV patients).
- It does not affect subcutaneous fat as much as visceral fat.
, Anti-age effects
- Improves skin condition (increases collagen synthesis).
- Supports bone density.
- May slow down sarcopenia (muscle loss with age).
, Cognitive benefits
- Potentially protects against neurodegeneration (Alzheimer’s disease).
- Improves sleep quality (by normalizing GH secretion).
④ Sports application
- Minor anabolic effect (less pronounced than that of IPA/The GRF mod).
- Faster recovery from injuries.
3. Application Protocols
Medical dosages (for lipodystrophy)
- 2 mg subcutaneously once a day (standard regimen).
- Course: 6-12 months.
For fat burning/anti-aging therapy
- 1-2 mg / day (in the evening or in the morning on an empty stomach).
- Optimal course: 3-6 months.
Комбинации Combinations with other peptides
- + CJC-1295 (without DAC) — increased GH emission.
- + Ipamorelin -synergy without prolactin growth.
4. Side effects
- Hyperglycemia (GH reduces insulin sensitivity).
- Edema/tunnel syndrome (fluid retention).
- Headaches (rare).
- Activation of latent tumors (contraindicated in oncology).
Important: Monitor blood sugar and IGF-1 levels during the course.
5.Tezamorelin vs. Other peptides
| The peptide | Main action | Hunger | Prolactin risk |
|---|---|---|---|
| Thesamorelin | Reducing visceral fat | No | Low |
| GHRP-6 | Powerful GH release + Appetite | Yes | Moderate |
| Ipamorelin | Pure GH-stimulus without hunger | No | Low |
| CJC-1295 | Prolonged GH secretion | No | Low |
6. Withdrawal
Tesamorelin is the best choice for:
✔ Reducing visceral fat (especially in patients with metabolic disorders).
✔ Anti-aging therapy (without sudden GH spikes).
✔ Safe course (less side effects than GHRP-2/6).
Recommendations:
- Start with 1 mg / day, control IGF-1.
- Combine with diet and exercise for maximum fat burning.
- It is contraindicated for tumors, pregnancy, and diabetes.
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